PGC-1 coactivates estrogen-related receptor- to induce the expression of glucokinase
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چکیده
Liu-Luan Zhu,* Yang Liu,* An-Fang Cui, Di Shao, Ji-Chao Liang, Xiao-Jun Liu, Yong Chen, Nishith Gupta, Fu-De Fang, and Yong-Sheng Chang National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing; Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei University, Wuhan, China; and Department of Molecular Parasitology, Humboldt University, Berlin, Germany
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Estrogen-related receptor (ERR ) is one of the first orphan nuclear receptors to be identified, yet its physiological functions are still unclear. We show here that ERR is an effector of the transcriptional coactivator PGC-1 [peroxisome proliferator-activated receptor (PPAR ) coactivator 1 ], and that it regulates the expression of genes involved in oxidative phosphorylation and mitochondrial b...
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تاریخ انتشار 2010